Obesity prevention and treatment using probiotics and prebiotics

Abstract

Obesity and other metabolic disorders are major health problems that can lead to cardiovascular disease, type 2 diabetes, musculoskeletal ailments, and a variety of cancers. There is a link between gut microbiota and metabolic problems, according to recent research. It was shown that the composition of the gut microbiota differs significantly between lean and obese people. The host's metabolism, as well as the immune and endocrine systems, are influenced by gut microorganisms. These microbes can alter the host's ability to store or get energy from food goods by regulating gene expression. To keep the host's health intact, it's critical to maintain a good balance of intestinal microbiota through proper diet and the use of probiotics and prebiotics. In our review, a total of 36 papers were examined (25 human and 11 animal trials). The duration of the trials ranged from four weeks to ten years, with 12 weeks being the most prevalent test period. The impact of gut microorganisms, probiotics, and prebiotics on many processes that contribute to the aforementioned metabolic condition is also examined, providing a comprehensive overview of the subject.